欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-ATP Citrate Lyase (ACL, ACLY) -EVT0185
EVT0185

Chemical Structure : EVT0185

CAS No.: 2588489-03-4

加入收藏

EVT0185 (EVT-0185)

货号: PC-25220Not For Human Use, Lab Use Only.

EVT0185 (EVT-0185) is a novel, orally available small molecule inhibitor of ATP citrate lyase (ACLY), inhibits de novo lipogenesis with IC50 of 0.46 uM in mouse primary hepatocytes.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    EVT0185 (EVT-0185) is a novel, orally available small molecule inhibitor of ATP citrate lyase (ACLY), inhibits de novo lipogenesis with IC50 of 0.46 uM in mouse primary hepatocytes.
    EVT0185 is activated in hepatocytes via SLC27A2-dependent conversion to its CoA-thioester form (EVT0185-CoA), allowing liver-specific action while sparing non-hepatic tissues.
    EVT0185-CoA directly interacts with the CoA-binding site of ACLY.
    EVT0185 more potently inhibits fatty acid and cholesterol synthesis from lactate and acetate than bempedoic acid (Cat#PC-43001) in WT hepatocytes.
    EVT0185-CoA inhibits rather than activated AMPKβ1-containing complexes, and also inhibits ACC1, ACC2 and ACSS2.
    EVT0185 also suppresses clonogenic survival of human (Hep3B) and mouse (Hepa1-6) HCC cell lines more effectively than bempedoic acid.
    EVT0185 (100 mg/kg) reduces tumour burden in distinct mouse models of MASH-HCC, promotes tumour-infiltrating B cells.

    物理化学性质&存储条件

    分子量 362.51
    分子式 C22H34O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-[4-(5-carboxy-5-methyl-hexyl)-phenyl]−2,2-dimethylhexanoic acid

    参考文献

    1. Gautam J, et al. ACLY inhibition promotes tumour immunity and suppresses liver cancer. Nature. 2025 Jul 30. doi: 10.1038/s41586-025-09297-0.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: