EVT-701 | Mitochondrial complex 1 inhibitor | Probechem Biochemicals

Chemical Structure : EVT-701

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EVT-701 (EVT701)

货号: PC-38785Not For Human Use, Lab Use Only.

EVT-701 is a highly potent, selective, and safe mitochondrial complex 1 (MC1) inhibitor, reduces NADH abundance with IC50 of 300 nM.

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生物&药学活性

EVT-701 is a highly potent, selective, and safe mitochondrial complex 1 (MC1) inhibitor, reduces NADH abundance with IC50 of 300 nM.
EVT‐701 dose‐dependently inhibits NADH oxidation and phosphorylation of ADP into ATP by 80% at 7.5 uM.
EVT‐701 inhibits mitochondrial ATP production at nanomolar concentrations in 3 cell lines (IC50 values of 52, 81 and 74 nM for MD‐MB‐231, Hep3B, and U87, respectively).
EVT‐701 dose‐dependently inhibits mitochondrial ATP production with IC50 of 393 nM and proliferation with IC50 of 188 nM in OxPhos‐dependent NH B‐cell lymphomas.
EVT‐701 inhibits OxPhos metabolism and proliferation of non‐small cell lung cancer (NSCLC) lines in vitro and in vivo.
EVT‐701 potently inhibits mitochondrial ATP production (IC50 of 203 nM) and proliferation of H460 cells (IC50 of 68 nM), but also induces apoptosis with an IC50 of 96 nM.

物理化学性质&存储条件

分子量	629.724
分子式	C35H35NO8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,1'R)-2,2'-((thiazole-2,4-diylbis(4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)ethan-1-ol)

参考文献

1. Raquel Luna Yolba, et al. Pharmacol Res Perspect. 2021 Oct;9(5):e00854.

EVT-701 (EVT701)

生物&药学活性

物理化学性质&存储条件

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EVT-701 (EVT701)

生物&药学活性

物理化学性质&存储条件

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