EVP4593 | nSOC inhibitor | Probechem Biochemicals

Chemical Structure : EVP4593

CAS No.: 545380-34-5

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EVP4593 (EVP-4593, QNZ)

货号: PC-20991Not For Human Use, Lab Use Only.

EVP4593 (EVP-4593) is an inhibitor of PMA/PHA-induced NF-κB pathway activation with IC50 of 9 nM, inhibits storeoperated calcium (Ca2+) entry (SOC) pathway in huntington's disease (HD) neurons.

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100 mg	￥4980	In stock
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生物&药学活性

EVP4593 (EVP-4593, QNZ) is an inhibitor of PMA/PHA-induced NF-κB pathway activation with IC50 of 9 nM, inhibits storeoperated calcium (Ca2+) entry (SOC) pathway in huntington's disease (HD) neurons.
EVP4593 inhibits store-operated Ca2+ entry in HD striatal neurons.
EVP4593 inhibits TRPC1-supported SOC Ca2+ currents in neuronal cells. protect YAC128 MSNs from glutamate-induced apoptosis.
EVP4593 reduces synaptic nSOC and rescues spine loss in YAC128 MSNs, intraventricular delivery of EVP4593 in YAC128 mice rescued age-dependent striatal spine loss in vivo.

物理化学性质&存储条件

分子量	356.43
分子式	C22H20N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	NC1=CC2=C(NCCC3=CC=C(OC4=CC=CC=C4)C=C3)N=CN=C2C=C1

参考文献

1. Wu J, et al. Chem Biol. 2011 Jun 24;18(6):777-93.

2. Tobe M, et al. Bioorg Med Chem. 2003b;11:3869–3878.

3. Wu J, et al. J Neurosci. 2016 Jan 6;36(1):125-41.

EVP4593 (EVP-4593, QNZ)

生物&药学活性

物理化学性质&存储条件

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EVP4593 (EVP-4593, QNZ)

生物&药学活性

物理化学性质&存储条件

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