EU-5346 | Mcl-1 inhibitor | Probechem Biochemicals

Chemical Structure : EU-5346

CAS No.: 315698-17-0

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EU-5346 (ML311, EU5346, ML 311)

货号: PC-38265Not For Human Use, Lab Use Only.

EU-5346 (ML311) is a small molecule Mcl-1 inhibitor with IC50 of 0.31 uM, potently and selectively disrupts Mcl-1/Bim interaction.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
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100 mg		Get quote

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生物&药学活性

EU-5346 (ML311) is a small molecule Mcl-1 inhibitor with IC50 of 0.31 uM, potently and selectively disrupts Mcl-1/Bim interaction.
EU-5346 induced cell death and decreased spheroid formation in Her2-positive BC cells.
EU-5346 induced ubiquitination of Mcl-1- bound Her2 demonstrating a previously unknown role for Mcl-1 to stabilize Her2 protein levels.
When combined with tamoxifen or trastuzumab, EU-5346 induced significant anti-BC activity in hormone receptor positive or Her2-positive BC cells, respectively.
EU-5346 in combination with paclitaxel induced synergistic anti-BC activity in both paclitaxel-sensitive and paclitaxel-resistant TNBC cells.

物理化学性质&存储条件

分子量	415.46
分子式	C23H24F3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO
Chemical Name/SMILES	7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol

参考文献

1. Bannister T, et al. Probe Reports from the NIH Molecular Libraries Program [Internet] 2012.

2. Bashari MH, et al. Breast Cancer Res. 2016 Feb 26;18(1):26.

EU-5346 (ML311, EU5346, ML 311)

生物&药学活性

物理化学性质&存储条件

参考文献

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EU-5346 (ML311, EU5346, ML 311)

生物&药学活性

物理化学性质&存储条件

参考文献

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