ETX1975-3

Chemical Structure : ETX1975-3

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货号: PC-28619Not For Human Use, Lab Use Only.

ETX1975-3 is a potent Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase (Cyt-bd) inhibitor with ATP IC50 of 1.7 uM and MIC of 5.0 uM for M. abscessus ΔqcrCAB strain.

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100 mg		Get quote

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生物&药学活性

ETX1975-3 is a potent Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase (Cyt-bd) inhibitor with ATP IC50 of 1.7 uM and MIC of 5.0 uM for M. abscessus ΔqcrCAB strain.
ETX1975-3 inhibits oxygen consumption with IC50 values of 0.6 mM in M. tuberculosis N0145 and 5.6 mM in M. tuberculosis H37Rv.
ETX1975-3 targets cyt-bd, and that the drug disrupts the electron transfer between the b-hemes centers.
tuberculosis H37Rv.
ETX1975-3 in combination with Q203, is bactericidal against M. tuberculosis, retains activity against a panel of M/XDR M. tuberculosis clinical isolates, and also shows efficacy against nontuberculous mycobacteria (NTM).

物理化学性质&存储条件

分子量	366.82
分子式	C20H16ClFN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1S,2R)-2-(4-chlorophenyl)cyclopropyl)-8-fluoro-2-methylpyrazolo[1,5-a]quinazolin-5-amine

参考文献

1. Samsher Singh, et al. J Med Chem. 2026 Feb 12;69(3):2130-2144.

ETX1975-3

生物&药学活性

物理化学性质&存储条件

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ETX1975-3

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物理化学性质&存储条件

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