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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-ETX0462
ETX0462

Chemical Structure : ETX0462

CAS No.: 2233569-54-3

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ETX0462 (ETX-0462)

货号: PC-72522Not For Human Use, Lab Use Only.

ETX0462 (ETX-0462) is a novel antibiotic with broad-spectrum activity for drug-resistant infections, inhibits Pseudomonas aeruginosa PAO1 with MIC of 0.5 mg/mL.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ETX0462 (ETX-0462) is a novel antibiotic with broad-spectrum activity for drug-resistant infections, inhibits Pseudomonas aeruginosa PAO1 with MIC of 0.5 mg/mL.
    ETX0462 has potent in vitro and in vivo activity against Pseudomonas aeruginosa plus all other Gram-negative ESKAPE pathogens, Stenotrophomonas maltophilia and biothreat pathogens.
    ETX0462 maintains activity in presence of all four Ambler classes of β-lactamases.
    ETX0462 also retains activity against recent CAZ/AVI-resistant KPC-3 variants.
    ETX0462 displays broad-spectrum Gram-negative potency against contemporary clinical isolates of 'KAPE'pathogens.
    ETX0462 also active against S. maltophilia and biothreat pathogens, including B. pseudomallei and B. mallei.
    ETX0462 demonstrated robust activity in neutropenic murine thigh efficacy model (7 P.a. strains).

    物理化学性质&存储条件

    分子量 330.319
    分子式 C10H14N6O5S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4R,8S)-8-((Z)-N'-hydroxy-N-methylcarbamimidoyl)-1-methyl-6-oxo-4,8-dihydro-1H-4,7-methanopyrazolo[3,4-e][1,3]diazepine-5(6H)-sulfonic acid

    参考文献

    1. Thomas F Durand-Reville, et al. Nature. 2021 Sep;597(7878):698-702.

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