ETG-5773 | NaCT inhibitor | Probechem Biochemicals

Chemical Structure : ETG-5773

CAS No.: 23794-80-1

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ETG-5773 (ETG5773)

货号: PC-49269Not For Human Use, Lab Use Only.

ETG-5773 (ETG5773) is a selective, cross-species active, non-competitive, non-substrate-like inhibitor of NaCT (SLC13A5, INDY), reduces citrate uptake in cell lines expressing mouseor human NaCT with IC50 of 180 and 160 nM, respectively.

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10 mg	￥3280	In stock
25 mg	￥5280	In stock
50 mg	￥7280	In stock
100 mg		Get quote

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生物&药学活性

ETG-5773 (ETG5773) is a selective, cross-species active, non-competitive, non-substrate-like inhibitor of NaCT (SLC13A5, INDY), reduces citrate uptake in cell lines expressing mouseor human NaCT with IC50 of 180 and 160 nM, respectively.
ETG-5773 displays no activiity on the closely related human NaDC3 (SLC13A3) transporter at 20 uM.
ETG-5773 (15 mg/kg twice-daily, oral) ameliorates diet-induced obesity in DIO mice.
ETG-5773 attenuates hepatic steatosis and regulates lipogenesis-related genes, significantly downregulates Acly mRNA levels.
ETG-5773 is able to reduce liver fat and other features of metabolically associated fatty liver disease (MAFLD).

物理化学性质&存储条件

分子量	335.630
分子式	C11H8ClF6NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,3,3-trifluoropropyl (3-chloro-5-(trifluoromethyl)phenyl)carbamate

参考文献

1. Grit Zahn, et al. Metabolites. 2022 Aug 8;12(8):732.

ETG-5773 (ETG5773)

生物&药学活性

物理化学性质&存储条件

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ETG-5773 (ETG5773)

生物&药学活性

物理化学性质&存储条件

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