ETC-451 | Wntless inhibitor | Probechem Biochemicals

Chemical Structure : ETC-451

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ETC-451 (ETC-2188451, ETC451)

货号: PC-22869Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ETC-451 (ETC-2188451) is a specific small molecule inhibitor of the Wnt transporter Wntless (WLS/Evi) with IC50 of 7.7 uM in Wnt/β-catenin reporter assays in STF3A cells, blocks the interaction of Wnt with Wntless.
ETC-2188451 selectively inhibits signaling in STF3A cells, but not in STF cells stimulated with WNT3A-conditioned medium, also does not block signaling resulting from downstream stimuli including activated LRP6 (ΔN-LRP6), stabilized β-catenin (β-catenin S45A mutant) and a GSK3 inhibitor BIO.
ETC-2188451 (5-50 uM) decreases WNT3A protein secretion in the culture supernatants and lysates of STF3A cells.
ETC-451 (0-40 uM) reduces Wnt target gene expression and colony formation in Wnt sensitive pancreatic cells, including AXIN2 and RNF43, also causes the upregulation of differentiation markers such as MUC.

物理化学性质&存储条件

分子量	346.45
分子式	C16H22N6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(aminomethyl)-N-(1-(tetrahydro-2H-thiopyran-4-yl)-1H-pyrazol-3-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxamide

参考文献

1. Yu J, et al. iScience. 2024 Jul 5;27(8):110454.

ETC-451 (ETC-2188451, ETC451)

生物&药学活性

物理化学性质&存储条件

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ETC-451 (ETC-2188451, ETC451)

生物&药学活性

物理化学性质&存储条件

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