ETC-206 (Tinodasertib, ETC-1907206) | MNK1/2 inhibitor

Chemical Structure : ETC-206

CAS No.: 1464151-33-4

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ETC-206 (Tinodasertib, ETC206, ETC-1907206)

货号: PC-63366Not For Human Use, Lab Use Only.

ETC-206 (Tinodasertib, ETC-1907206) is a potent, selective MNK1/2 inhibitor with IC50 of 64/86 nM, inhibits eIF4E phosphorylation inhibition in HeLa cell line with IC50 of 321 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg	￥4380	In stock
100 mg		Get quote

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生物&药学活性

ETC-206 (Tinodasertib, ETC-1907206) is a potent, selective MNK1/2 inhibitor with IC50 of 64/86 nM, inhibits eIF4E phosphorylation inhibition in HeLa cell line with IC50 of 321 nM.
ETC-206 (Tinodasertib) displays excellent kinase selectivity, inhibits only 2 kinases by >65% at 1 uM against a panel of 104 kinases.
ETC-206 (Tinodasertib) demonstrates potent anti-proliferative activity against 25 hematological cancer cell lines with submicromolar IC50, especially against GK-5, DOHH2, AHH1 and P3HR-1 cell lines.
ETC-206 (Tinodasertib) prevents BC CML LSC self-renewal in vitro, significantly enhances the anti-tumor activity of dasatinib in BC CML mouse xenograft model.

物理化学性质&存储条件

分子量	408.461
分子式	C25H20N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile

参考文献

1. Yang HY, et al. J Med Chem. 2018 Apr 23. doi: 10.1021/acs.jmedchem.7b01714.

ETC-206 (Tinodasertib, ETC206, ETC-1907206)

生物&药学活性

物理化学性质&存储条件

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ETC-206 (Tinodasertib, ETC206, ETC-1907206)

生物&药学活性

物理化学性质&存储条件

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