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首页-小分子抑制剂&激动剂-Others-Other Targets-ESI-09
ESI-09

Chemical Structure : ESI-09

CAS No.: 263707-16-0

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ESI-09 (ESI09, ESI 09)

货号: PC-45049Not For Human Use, Lab Use Only.

ESI-09 is a specific, noncyclic nucleotide EPAC antagonist (IC50=9 uM) with no effect towards PKA.

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10 mg ￥880 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ESI-09 is a specific, noncyclic nucleotide EPAC antagonist (IC50=9 uM) with no effect towards PKA.
ESI-09 specifically blocks intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic β cells.
ESI-09 inhibits cAMP-mediated EPAC2 GEF activity and cAMP-mediated EPAC1 GEF activity with IC50 of 1.4 and 3.2 uM, respectively.
ESI-09 inhibits pancreatic cancer cell migration and invasion.

物理化学性质&存储条件

分子量 330.7689
分子式 C16H15ClN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 47 mg/mL
Chemical Name/SMILES

3-Isoxazolepropanenitrile, α-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-

参考文献

1. Almahariq M, et al. Mol Pharmacol. 2013 Jan;83(1):122-8.

2. Singhmar P, et al. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3036-41.

3. Wang H, et al. Sci Rep. 2016 Nov 10;6:36552.

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