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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-ESG-1-61
ESG-1-61

Chemical Structure : ESG-1-61

CAS No.: 2899250-98-5

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ESG-1-61

货号: PC-24332Not For Human Use, Lab Use Only.

ESG-1-61 is a potent, selective antagonist/inverse agonist of dopamine D3 receptor (D3R) with Ki of 0.73 nM, EC50 of 3.36 nM (Go activation) and4.36 nM (β-arrestin2 recruitment), show ~20-fold binding selectivity for D3 over D2 receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ESG-1-61 is a potent, selective antagonist/inverse agonist of dopamine D3 receptor (D3R) with Ki of 0.73 nM, EC50 of 3.36 nM (Go activation) and4.36 nM (β-arrestin2 recruitment), show ~20-fold binding selectivity for D3 over D2 receptors.

物理化学性质&存储条件

分子量 466.06
分子式 C25H40ClN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Propanamide, N-[trans-4-[2-[4-(3-chloro-5-ethyl-2-methoxyphenyl)-1-piperazinyl]ethyl]cyclohexyl]-3-methoxy-

参考文献

1. Soler-Cedeño O, et al. Br J Pharmacol. 2025 Mar 27. doi: 10.1111/bph.70021.

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