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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-11β-HSD-ESC1002755
ESC1002755

Chemical Structure : ESC1002755

CAS No.: 2915567-21-2

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ESC1002755

货号: PC-24917Not For Human Use, Lab Use Only.

ESC1002755 is a highly potent 17β-Hydroxysteroid type 10 (17β-HSD10) inhibitor with IC50 of 19 nM in biochemical assays, inhibits cellular 17β-HSD10 activity with EC50 of 28 nM in stable HEK 293 cell line overexpressing 17β-HSD10.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ESC1002755 is a highly potent 17β-Hydroxysteroid type 10 (17β-HSD10) inhibitor with IC50 of 19 nM in biochemical assays, inhibits cellular 17β-HSD10 activity with EC50 of 28 nM in stable HEK 293 cell line overexpressing 17β-HSD10.

物理化学性质&存储条件

分子量 383.89
分子式 C21H18ClNO2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-(3-chlorothiophen-2-yl)(2-(3'-hydroxy-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)methanone

参考文献

1. Aitken L, et al. ACS Chem Biol. 2025 Jun 18. doi: 10.1021/acschembio.5c00110.

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