ERP1.28a | CDC-7 inhibitor | Probechem Biochemicals

Chemical Structure : ERP1.28a

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ERP1.28a (CDC-7 inhibitor)

货号: PC-38769Not For Human Use, Lab Use Only.

ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.
ERP1.28a prevents cytosolic accumulation of TDP-43.
ERP1.28a treatment leads to recovering the nuclear function of TDP-43-inducing CDK6 repression in FTLD-TDP lymphoblasts.

物理化学性质&存储条件

分子量	276.742
分子式	C12H9ClN4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((3-chlorobenzyl)thio)-9H-purine

参考文献

1. Vaca G, et al. J Neurochem. 2021 Feb;156(3):379-390.