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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Other Viruses-ERDRP-0519
ERDRP-0519

Chemical Structure : ERDRP-0519

CAS No.: 1374006-96-8

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ERDRP-0519 (ERDRP0519)

货号: PC-72591Not For Human Use, Lab Use Only.

ERDRP-0519 (ERDRP0519) is a specific, orally bioavailable small-molecule viral polymerase inhibitor (CDV/MeV polymerase IC50=0.4/0.6 uM), shows pan-morbillivirus inhibitory activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ERDRP-0519 (ERDRP0519) is a specific, orally bioavailable small-molecule viral polymerase inhibitor (CDV/MeV polymerase IC50=0.4/0.6 uM), shows pan-morbillivirus inhibitory activity.
ERDRP-0519 displayed vitro efficacy against a panel of MeV isolates representing seven distinct, currently endemic genotypes with EC50 values of 0.07-0.3 uM.
ERDRP-0519 potently inhibited morbillivirus-derived polymerase complexes, does not inhibit a distant member of the paramyxovirus family, respiratory syncytial virus (RSV).
ERDRP-0519 demonstrated oral efficacy gainst pathogenic CDV in ferrets.
ERDRP-0519 inhibits all phosphodiester bond formation in both de novo initiation of RNA synthesis at the promoter and RNA elongation by a committed polymerase complex.
ERDRP-0519 prevents measles virus (MeV) infection in squirrel monkeys (Saimiri sciureus).
ERDRP-0519 inhibits feline coronavirus (FCoV) in vitro.

物理化学性质&存储条件

分子量 529.579
分子式 C23H30F3N5O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

100 mM in DMSO (52.9 mg/mL)
Chemical Name/SMILES

1-Methyl-N-[4-[[(2S)-2-[2-(4-morpholinyl)ethyl]-1-piperidinyl]sulfonyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

参考文献

1. Stefanie A Krumm, et al. Sci Transl Med. 2014 Apr 16;6(232):232ra52.

2. Kevin Wittwer, et al. Nat Commun. 2021 Sep 2;12(1):5233.

3. Cox RM, et al. PLoS Pathog. 2021 Feb 23;17(2):e1009371.

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