ERAP1 inhibitor 3

Chemical Structure : ERAP1 inhibitor 3

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货号: PC-72272Not For Human Use, Lab Use Only.

ERAP1 inhibitor 3 is a selective, small molecule inhibitor of ERAP1 with IC50 of 0.4 uM, displays no inhibitory effect against its paralogues ERAP2 and IRAP.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

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生物&药学活性

ERAP1 inhibitor 3 is a selective, small molecule inhibitor of ERAP1 with IC50 of 0.4 uM, displays no inhibitory effect against its paralogues ERAP2 and IRAP.
ERAP1 inhibitor 3 allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates.
ERAP1 inhibitor 3 inhibited antigen presentation in a cellular assay.
Compound 3 displays higher potency for an ERAP1 variant associated with increased risk of autoimmune disease.

物理化学性质&存储条件

分子量	458.452
分子式	C20H21F3N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
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Solubility
Chemical Name/SMILES

参考文献

1. Zachary Maben, et al. J Med Chem. 2020 Jan 9;63(1):103-121.