ERAD inhibitor CP26 | Dislocation inhibitor | Probechem Biochemicals

Chemical Structure : ERAD inhibitor CP26

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ERAD inhibitor CP26 (NSC26112, MLS000738051)

货号: PC-20569Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

ERAD inhibitor CP26 (NSC26112) is a small molecule inhibitor of Hrd1 complex-mediated dislocation, inhibits NHK dislocation in HeLa cells with IC50 of 4.45 μM in the drGFP assays, shows broad-spectrum anti-flavivirus activity.
CP26 inhibited CD3δ dislocation with an IC50 of 34.97 μM in the drGFP assay in Hela cells.
CP26 inhibited dislocation by targeting a protein within the Hrd1 complex.
CP26 inhibited NHK ubiquitination and degradation.
CP26 activates the UPR, inhibits cholera toxin stimulated cAMPin Hela cells with IC50 of 1.1 uM, but not ricin activity.
CP26 (200 nM) exhibited broad spectrum anti-DENV and anti-ZIKA activity in Huh-7 cells.

物理化学性质&存储条件

分子量	306.01
分子式	C13H8Cl4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ClC1=C(Cl)C(Cl)=C(Cl)/C1=C/C2=CC=C(C)C=C2

参考文献

1. Jingjing Ruan, et al. Sci Rep. 2019 Jul 29;9(1):10901.

ERAD inhibitor CP26 (NSC26112, MLS000738051)

生物&药学活性

物理化学性质&存储条件

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ERAD inhibitor CP26 (NSC26112, MLS000738051)

生物&药学活性

物理化学性质&存储条件

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