ER-819762 | EP4 antagonist | Probechem Biochemicals

Chemical Structure : ER-819762

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ER-819762 (ER819762)

货号: PC-61555Not For Human Use, Lab Use Only.

ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay.

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生物&药学活性

ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay.
ER-819762 inhibits EP4-stimulated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells.
ER-819762 exhibits no agonism or antagonism for the related PGE2 EP1, EP2 and EP3 receptors.
ER-819762 suppresses Th1 and Th17 cytokine production, suppresses disease in collagen- and GPI-induced arthritis in mice, and suppresses CFA-induced inflammatory pain in rats.

物理化学性质&存储条件

分子量	489.65
分子式	C30H39N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1'-(3,5-dimethylbenzyl)-2-ethyl-7,9-dimethoxy-10-methyl-5,10-dihydrospiro[benzo[e]imidazo[1,5-a]azepine-1,4'-piperidin]-3(2H)-one

参考文献

1. Chen Q, et al. Br J Pharmacol. 2010 May;160(2):292-310.

2. Jones VC, et al. Br J Pharmacol. 2016 Mar;173(6):992-1004.

ER-819762 (ER819762)

生物&药学活性

物理化学性质&存储条件

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ER-819762 (ER819762)

生物&药学活性

物理化学性质&存储条件

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