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首页-小分子抑制剂&激动剂-Epigenetics-Histone Acetyltransferase (HAT)-EPS496
EPS496

Chemical Structure : EPS496

CAS No.: 824419-29-6

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EPS496 (EPS-496)

货号: PC-24033Not For Human Use, Lab Use Only.

EPS496 is a small molecule inhibitor of histone acetyltransferase p300, binds effectively to p300 and inhibits p300 kinase activation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EPS496 is a small molecule inhibitor of histone acetyltransferase p300, binds effectively to p300 and inhibits p300 kinase activation.
EPS496 effectively inhibited the proliferation of normal melanoma cells with GI50 values of 367.8 nM, 986.4 nM, and 642.1 nM in A375, SK-MEL-28, and A2058 respectively. 
EPS496 promoted early and late-phase apoptosis in vemurafenib-resistant melanoma cells.
EPS496 inhibited p300 in vemurafenib-resistant melanoma cells.

物理化学性质&存储条件

分子量 454.87
分子式 C26H15ClN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-chloro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-9-hydroxy-9H-fluorene-9-carboxamide

参考文献

1. Maha Alamodi Alghamdi, et al. Biochem Biophys Res Commun. 2025 Mar 1:750:151382.

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