EPIC-0412 | HOTAIR-EZH2 inhibitor | Probechem Biochemicals

Chemical Structure : EPIC-0412

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EPIC-0412 (EPIC0412)

货号: PC-49393Not For Human Use, Lab Use Only.

EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis.

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生物&药学活性

EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis.
EPIC-0412 physically interrupts the binding of HOTAIR and EZH2, leading to the upregulation of CDKN1A and BBC3, causing cell cycle arrest and apoptosis in GBM cells.
EPIC-0412 inhibits DNA damage response in GBM cells through the p21-E2F1 DNA damage repair axis.
EPIC-0412 epigenetically silences MGMT through its interaction with the ATF3-p-p65-HADC1 axis at the MGMT promoter region.
EPIC-0412 restored the TMZ sensitivity in GBM in vivo experiments.

物理化学性质&存储条件

分子量	423.387
分子式	C21H18F5N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-((2,4-difluorobenzyl)oxy)benzyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine

参考文献

1. Zhao J, et al. Neuro Oncol. 2022 Oct 22:noac242.

EPIC-0412 (EPIC0412)

生物&药学活性

物理化学性质&存储条件

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EPIC-0412 (EPIC0412)

生物&药学活性

物理化学性质&存储条件

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