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首页-小分子抑制剂&激动剂-Apoptosis-Ferroptosis-EPI-743
EPI-743

Chemical Structure : EPI-743

CAS No.: 1213269-98-7

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EPI-743 (Vatiquinone, PTC-743, alpha-tocotrienol quinone, ATQ3)

货号: PC-61856Not For Human Use, Lab Use Only.

EPI-743 (Vatiquinone, ATQ3) is an orally bioavailable para-benzoquinone and vitamin-E related compound, shows potent cellular protectant against oxidative stress and aging, inhibits RSL3-induced ferroptosis.

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10 mg ￥1980 In stock
25 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EPI-743 (Vatiquinone, ATQ3) is an orally bioavailable para-benzoquinone and vitamin-E related compound, shows potent cellular protectant against oxidative stress and aging, inhibits RSL3-induced ferroptosis.
EPI-743 (Vatiquinone, ATQ3) prevents RSL3-induced ferroptosis in PCH6 patient fibroblasts with mean EC50 potency values of 17.3-21.8 nM.
EPI-743 (Vatiquinone, ATQ3) is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies.
EPI-743 (Vatiquinone, ATQ3) shows potential for treatment of inherited mitochondrial diseases.
EPI-743 (Vatiquinone, ATQ3) is an analogue of the antioxidant ubidecarenone.

物理化学性质&存储条件

分子量 440.668
分子式 C29H44O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((R,6E,10E)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trien-1-yl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione

参考文献

1. Enns GM, et al. Mol Genet Metab. 2012 Jan;105(1):91-102.
2. Martinelli D, et al. Mol Genet Metab. 2012 Nov;107(3):383-8.
3. Sadun AA, et al. Arch Neurol. 2012 Mar;69(3):331-8.
4. Shrader WD, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3693-8.

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