EPI-001 | AR NTD inhibitor | Probechem Biochemicals

Chemical Structure : EPI-001

CAS No.: 227947-06-0

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EPI-001 (EPI001)

货号: PC-61678Not For Human Use, Lab Use Only.

EPI-001 is a small molecule that blocks transactivation of the androgen Receptor (AR) NTD (IC50=6 uM) and specificly inhibits AR without attenuating transcriptional activities of related steroid receptors.

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25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
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生物&药学活性

EPI-001 (EPI 001) is a small molecule that blocks transactivation of the androgen receptor (AR) NTD (IC50=6 uM) and specificly inhibits AR without attenuating transcriptional activities of related steroid receptors.
EPI-001 targets the transactivation unit 5 of AR and interacts with AF-1 in the NTD to prevent protein-protein interactions.
EPI-001 inhibits endogenous expression of androgen-regulated genes, inhibits both androgen-dependent and androgen-independent (OCM-induced) proliferation of LNCaP cells.
EPI-001 reduces the growth of CRPC xenografts; also is a selective PPAR-gamma modulator.

物理化学性质&存储条件

分子量	394.89
分子式	C21H27ClO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-1,2-propanediol

参考文献

1. Myung JK, et al. J Clin Invest. 2013 Jul;123(7):2948-60.

2. De Mol E, et al. ACS Chem Biol. 2016 Sep 16;11(9):2499-505.

3. Andersen RJ, et al. Cancer Cell. 2010 Jun 15;17(6):535-46.

4. Brand LJ, et al. Oncotarget. 2015 Feb 28;6(6):3811-24.

EPI-001 (EPI001)

生物&药学活性

物理化学性质&存储条件

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EPI-001 (EPI001)

生物&药学活性

物理化学性质&存储条件

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