EPB-113 | Coronavirus inhibitor | Probechem Biochemicals

Chemical Structure : EPB-113

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EPB-113 (EPB113)

货号: PC-23977Not For Human Use, Lab Use Only.

EPB-113 is a potent replication inhibitor of HCoV-229E with EC50 of 0.48 uM, also suppresses SARS-CoV-2, binds to hexameric nsp15 protein.

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生物&药学活性

EPB-113 is a potent replication inhibitor of HCoV-229E with EC50 of 0.48 uM, also suppresses SARS-CoV-2, binds to hexameric nsp15 protein.
EPB-113 shows an EC90 value of 0.65 µM based on RT-qPCR for viral genome copies and of 0.40 µM based on titration of infectious virus inHCoV-229E-infected HEL299 cells.
EPB-113 inhibits SARS-CoV-2 replication in A549ACE2/TMPRSS2 cells. The molecule was shown to have an EC90 value (by RT-qPCR for viral load) of 12 µM and to produce more than 5-log10 reduction in viral load at 50 µM.
The antiviral effect of EPB-113 is tightly linked with nsp15, and specifically its EndoU domain, enhances the EndoU cleavage reaction
EPB-113 is active in both IFN responsive and non-responsive cell types.
EPB-113 acts at a post-entry and intermediate stage in first-cycle HCoV-229E replication.

物理化学性质&存储条件

分子量	395.35
分子式	C14H14F5N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=CC=CC(NC(N)=N)=C1)NC2=CC(S(F)(F)(F)(F)F)=CC=C2

参考文献

1. Van Loy B, et al. PLoS Pathog. 2025 Feb 11;21(2):e1012571.

EPB-113 (EPB113)

生物&药学活性

物理化学性质&存储条件

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EPB-113 (EPB113)

生物&药学活性

物理化学性质&存储条件

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