EP4R antagonist 74

Chemical Structure : EP4R antagonist 74

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货号: PC-21514Not For Human Use, Lab Use Only.

EP4R antagonist 74 is a potent, selective EP4 receptor antagonist with Ki of 11.2 nM, shows apparent dissociation constant KB of 16 nM in functional cAMP production-based assays.

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1 g		Get quote

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生物&药学活性

EP4R antagonist 74 is a potent, selective EP4 receptor antagonist with Ki of 11.2 nM, shows apparent dissociation constant KB of 16 nM in functional cAMP production-based assays.
EP4R antagonist 74 shows no binding to EP1, EP2 or EP3 receptors in 3H-PGE2 displacement assays, and no off-target activities against the prostaglandin D2 or thromboxane A2 receptors.

物理化学性质&存储条件

分子量	368.41
分子式	C20H21FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((8-fluoro-9H-pyrimido[4,5-b]indol-4-yl)amino)spiro[3.5]nonane-7-carboxylic acid

参考文献

1. Gahbauer S, et al. Nat Commun. 2023 Dec 6;14(1):8067.