EP009 | JAK3 inhibitor | Probechem Biochemicals

Chemical Structure : EP009

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EP009 (EP-009;EP 009)

货号: PC-61263Not For Human Use, Lab Use Only.

EP009 is a selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.

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100 mg		Get quote

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生物&药学活性

EP009 is a selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.
EP009 exhibits limited off-target effects against a panel of 92 human kinases.
EP009 inhibits tyrosine phosphorylation and activation of JAK3/STAT3 in SU-DHL-1 cells, with activation of JNK1/2, but not p38.
EP009 displays a favorable cytotoxicity profile with therapeutic efficacy against JAK3-driven tumor T-cells in vitro, in vivo, and ex vivo.

物理化学性质&存储条件

分子量	224.344
分子式	C14H24O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(hydroxymethyl)-12-methylenecyclododecanone

参考文献

1. Ross JA, et al. Leukemia. 2014 Apr;28(4):941-4.

2. Martinez GS, et al. Clin Cancer Drugs. 2016;3(2):131-137.

EP009 (EP-009;EP 009)

生物&药学活性

物理化学性质&存储条件

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EP009 (EP-009;EP 009)

生物&药学活性

物理化学性质&存储条件

参考文献

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