EOAI3402143 | Usp9x/Usp24 inhibitor | Probechem Biochemicals

Chemical Structure : EOAI3402143

CAS No.: 1699750-95-2

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EOAI3402143 (Deubiquitinase inhibitor G9;EOAI 3402143)

货号: PC-61303Not For Human Use, Lab Use Only.

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor (IC50=1.6 uM).

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor (IC50=1.6 uM).
EOAI3402143 shows increased aqueous solubility and greater cellular Usp9x inhibitory activity than WP1130.
EOAI3402143 displays nM apoptotic activity against other myeloma cell lines and diffuse large B-cell lymphomas cells.
EOAI3402143 increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice; also inhibis Usp5.

物理化学性质&存储条件

分子量	503.424
分子式	C25H28Cl2N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide

参考文献

1. Peterson LF, et al. Blood. 2015 Jun 4;125(23):3588-97.

2. Potu H, et al. Oncotarget. 2014 Jul 30;5(14):5559-69.

EOAI3402143 (Deubiquitinase inhibitor G9;EOAI 3402143)

生物&药学活性

物理化学性质&存储条件

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EOAI3402143 (Deubiquitinase inhibitor G9;EOAI 3402143)

生物&药学活性

物理化学性质&存储条件

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