ENX-104 | D2/D3 receptor antagonist | Probechem Biochemicals

Chemical Structure : ENX-104

加入收藏

ENX-104 (ENX104)

货号: PC-26137Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ENX-104 is a highly selective and potent dopamine D2/D3 receptor antagonist with IC50 of 1.1 nM, 0.1 nM, 2.4 nM and 15.3 nM for D2-like inhibitory dopamine receptors D2S, D2L, D3, and D4 respectively.
ENX-104 displays potent binding and full antagonist activity for D2L with affinity of 0.01 nM (Ki), and 0.1 nM (IC50), also binds strongly to and displays potent antagonist activity at D2S (Ki = 0.1 nM, IC50 = 1.1 nM) and D3 (Ki = 0.2 nM, IC50 = 2.4 nM) receptors.
ENX-104 produced sustained increases in dopamine levels in the nucleus accumbens in rats.
ENX-104 enhanced reward responsiveness at low doses corresponding to approximately 10–50% D2/D3 receptor occupancy.

物理化学性质&存储条件

分子量	392.94
分子式	C21H21D5ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-2-methoxy-N-((2S,3S)-2-methyl-1-(phenylmethyl-d2)pyrrolidin-3-yl)-4-((methyl-d3)amino)benzamide

参考文献

1. Vadodaria KC, et al. Neuropsychopharmacology. 2025 Dec 7. doi: 10.1038/s41386-025-02287-w.

ENX-104 (ENX104)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ENX-104 (ENX104)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.