ENPP1 inhibitor QPS1 | ENPP1 inhibitor | Probechem Biochemicals

Chemical Structure : ENPP1 inhibitor QPS1

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ENPP1 inhibitor QPS1 (QPS1)

货号: PC-72235Not For Human Use, Lab Use Only.

ENPP1 inhibitor QPS1 (QPS1) is a potent, selective non-competitive inhibitor of Ectonucleotide pyrophosphatase/PDE1 (NPP1, ENPP1) with Ki of 59.3 nM.

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生物&药学活性

ENPP1 inhibitor QPS1 (QPS1) is a potent, selective non-competitive inhibitor of Ectonucleotide pyrophosphatase/PDE1 (NPP1, ENPP1) with Ki of 59.3 nM.
QPS1 also significantly inhibited the K121Q NPP1 gene variant with Ki of 59.2 nM.
QPS1 did not significantly alter the activity of other nucleotide metabolizing ectoenzymes expressed at the cell surface, namely NPP3, NTPDases (1–3), ecto-5′-nucleotidase and ALP.
QPS1 (10 uM) prevented phosphate-induced mineralization of VICs and lowered the rise of osteogenic genes as expected for NPP1 inhibition.
In ENPP1 null cells, QPS1 also increased intracellular cGAMP and decreased extracellular cGAMP concentrations, suggesting that it blocks the cGAMP exporter.
QPS1) inhibits extracellular cGAMP degradation in cells overexpressing ENPP1.

物理化学性质&存储条件

分子量	395.478
分子式	C17H25N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]ethyl]-Sulfamide

参考文献

1. Elnur Elyar Shayhidin, et al. Br J Pharmacol. 2015 Aug;172(16):4189-99.

ENPP1 inhibitor QPS1 (QPS1)

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物理化学性质&存储条件

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ENPP1 inhibitor QPS1 (QPS1)

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