ENOblock (AP-III-a4)

Chemical Structure : ENOblock

CAS No.: 1177827-73-4

加入收藏

货号: PC-20388Not For Human Use, Lab Use Only.

ENOblock (AP-III-a4) is a unique small molecule inhibitor of the glycolysis enzyme Enolase with IC50 of 576 nM, binds enolase and modulates its non-glycolytic functions.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ENOblock (AP-III-a4) is a unique small molecule inhibitor of the glycolysis enzyme Enolase with IC50 of 576 nM, binds enolase and modulates its non-glycolytic functions.
ENOblock induces enolase nuclear localization and modulates target gene expression in both hepatocytes and adipocytes.
ENOblock (12 mg/kg) reduces blood glucose, LDL cholesterol and enolase activity, also reduces the serum level of free fatty acid (FFA) in T2DM mice, without liver hepatocyte toxicity.
ENOblock reduces liver fibrosis and apoptosis in T2DM mice, inhibits the expression of inflammatory markers and key regulators of lipid homeostasis and gluconeogenesis in the T2DM liver.
ENOblock reduces cardiac hypertrophy, fibrosis, apoptosis and pathological markers in T2DM mice.
ENOblock significantly inhibits cancer cell invasion of HCT116 cancer cells at 625 nM, decreases the expression of AKT and Bcl-xL.
ENOblock can inhibit cancer cell metastasis in vivo.

物理化学性质&存储条件

分子量	594.74
分子式	C31H43FN8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-2-(4-((4-((cyclohexylmethyl)amino)-6-((4-fluorobenzyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)acetamide

参考文献

1. Cho H, et al. Sci Rep. 2017 Mar 8;7:44186.

2. Jung DW, et al. ACS Chem Biol. 2013;8(6):1271-82.