ENL YEATS Domain inhibitor 7

Chemical Structure : ENL YEATS Domain inhibitor 7

CAS No.: 2803461-76-7

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货号: PC-72712Not For Human Use, Lab Use Only.

ENL YEATS Domain inhibitor 7 is a selective, small molecule inhibitor of ENL YEATS Domain with IC50 of 0.62 uM in inhibiting the ENL-acetyl-H3 interaction.

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
50 mg	￥8980	In stock
100 mg		Get quote

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生物&药学活性

ENL YEATS Domain inhibitor 7 is a selective, small molecule inhibitor of ENL YEATS Domain with IC50 of 0.62 uM in inhibiting the ENL-acetyl-H3 interaction.
ENL YEATS Domain inhibitor 7 displayed strong selectivity toward the ENL YEATS domain over all other human YEATS domains.
ENL YEATS Domain inhibitor 7 exhibited on-target inhibition of ENL in cultured cells and a synergistic effect with the bromodomain and extraterminal domain inhibitor JQ1 in killing leukemia cells.

物理化学性质&存储条件

分子量	309.373
分子式	C17H19N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((dimethylamino)methyl)benzyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide

参考文献

1. Xinyu R Ma, et al. J Med Chem. 2021 Aug 12;64(15):10997-11013.