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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-EN523
EN523

Chemical Structure : EN523

CAS No.: 2094893-05-5

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EN523 (EN-523)

货号: PC-72835Not For Human Use, Lab Use Only.

EN523 (EN-523) is a small molecule covalent ligand that targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1, OTUB1 recruiter component of DUBTAC NJH-2-057.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EN523 (EN-523) is a small molecule covalent ligand that targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1, OTUB1 recruiter component of DUBTAC NJH-2-057.
Deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small molecules consisting of a deubiquitinase recruiter linked to a protein-targeting ligand, to stabilize the levels of specific proteins degraded in a ubiquitin-dependent manner.

物理化学性质&存储条件

分子量 234.255
分子式 C12H14N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-acryloyl-1-(5-methylfuran-2-yl)piperazin-2-one

参考文献

1. Henning NJ, et al. Nat Chem Biol. 2022 Feb 24. doi: 10.1038/s41589-022-00971-2.

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