EML741 | G9a/GLP inhibitor | Probechem Biochemicals

Chemical Structure : EML741

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EML741 (EML-741)

货号: PC-22921Not For Human Use, Lab Use Only.

EML741 is a potent, selective inhibitor of H3K9-specific methyltransferases G9a/G9a-like protein (G9a/GLP) with IC50 of 23 nM (G9a), KD of 1.13 uM in MST assays.

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生物&药学活性

EML741 is a potent, selective inhibitor of H3K9-specific methyltransferases G9a/G9a-like protein (G9a/GLP) with IC50 of 23 nM (G9a), KD of 1.13 uM in MST assays.
EML741 shows high selectivity against a panel of other epigenetic enzymes (KMT5A/SETD8, KDM4A/JMJD2A, PRMT1, PRMT3, KAT3B/p300).
EML741 (0.5 and 5 μM) induced a marked and both concentration- and time-dependent reduction in the dimethylation of lysine H3K9 in MCF-7 and MDA-MB-231 human breast adenocarcinoma cells.

物理化学性质&存储条件

分子量	523.77
分子式	C31H49N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Cyclohexyl-7-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-8-[3-(1-pyrrolidinyl)propoxy]-3H-1,4-benzodiazepin-5-amine

参考文献

1. Ciro Milite, et al. J Med Chem. 2019 Mar 14;62(5):2666-2689.

EML741 (EML-741)

生物&药学活性

物理化学性质&存储条件

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EML741 (EML-741)

生物&药学活性

物理化学性质&存储条件

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