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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-EML633
EML633

Chemical Structure : EML633

CAS No.: 2101954-85-0

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EML633 (EML-633)

货号: PC-70164Not For Human Use, Lab Use Only.

EML633 (EML 633) small-molecule inhibitor of methyllysine reader protein SPIN1 (Spindlin 1) with Kd of 2 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    EML633 (EML 633) small-molecule inhibitor of methyllysine reader protein SPIN1 (Spindlin 1) with Kd of 2 uM.
    EML 633 shows increased selectivity and engages SPIN1 in cells, block its ability to 'read' H3K4me3 marks and inhibit its transcriptional-coactivator activity.

    物理化学性质&存储条件

    分子量 682.998
    分子式 C42H62N6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2-((3-(2-(pyrrolidin-1-yl)ethyl)phenyl)amino)-1,4-phenylene)bis((4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)methanone)

    参考文献

    1. Bae N, et al. Nat Chem Biol. 2017 May 15. doi: 10.1038/nchembio.2377.

    2. Wang W, et al. EMBO Rep. 2011 Oct 28;12(11):1160-6.

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