EML1219 | PRMT9 inhibitor | Probechem Biochemicals

Chemical Structure : EML1219

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EML1219 (EML-1219 )

货号: PC-21013Not For Human Use, Lab Use Only.

EML1219 is a selective small molecule inhibitor of protein arginine methyltransferase isoform PRMT9 with IC50 of 0.2 uM.

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生物&药学活性

EML1219 is a selective small molecule inhibitor of protein arginine methyltransferase isoform PRMT9 with IC50 of 0.2 uM.
EML1219 is selective against a panel of SET-domain-containing proteins including ASH1L/KMT2H, EZH2/KMT6, MLL1/KMT2A, SET7/9/KMT7, SETD8/KMT5A, SUV39H2/KMT1B, and SUV420H1/KMT5B.

物理化学性质&存储条件

分子量	676.61
分子式	C28H31F3N10O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(OC)C1=CC(O)=C2C=C(NC(NCCCNC(NC[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=N)=O)C=C(C(F)(F)F)C2=C1

参考文献

1. Alessandra Feoli, et al. J Med Chem. 2023 Aug 10. doi: 10.1021/acs.jmedchem.3c01030.

EML1219 (EML-1219 )

生物&药学活性

物理化学性质&存储条件

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EML1219 (EML-1219 )

生物&药学活性

物理化学性质&存储条件

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