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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-SGK-EMD638683
EMD638683

Chemical Structure : EMD638683

CAS No.: 1181770-72-8

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EMD638683 (EMD 638683 )

货号: PC-21337Not For Human Use, Lab Use Only.

EMD638683 is a highly selective SGK1 inhibitor, inhibits SGK1-dependent phosphorylation of NDRG1 with IC50 of 3 uM in Hela cells.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EMD638683 is a highly selective SGK1 inhibitor, inhibits SGK1-dependent phosphorylation of NDRG1 with IC50 of 3 uM in Hela cells.
EMD638683 promotes radiation-induced suicidal death of colon tumor cells in vitro and decreases the number of colonic tumors following chemical carcinogenesis in vivo.
EMD638683 abrogates the salt sensitivity of blood pressure in hyperinsulinism without appreciably affecting blood pressure in the absence of hyperinsulinism in mice.

物理化学性质&存储条件

分子量 364.35
分子式 C18H18F2N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide

参考文献

1. Ackermann TF, et al. Cell Physiol Biochem. 2011;28(1):137-46.

2. Towhid ST, et al. Cell Physiol Biochem. 2013;32(4):838-48.

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