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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-EMD386088
EMD386088

Chemical Structure : EMD386088

CAS No.: 54635-62-0

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EMD386088 (EMD 386088)

货号: PC-20844Not For Human Use, Lab Use Only.

EMD386088 is a potent, selective 5-HT6 receptor agonist with EC50 of 1.0 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EMD386088 is a potent, selective 5-HT6 receptor agonist with EC50 of 1.0 nM.
EMD386088 displays selectivity over other 5-HT receptors (IC50 values are 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively.
EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.

物理化学性质&存储条件

分子量 246.74
分子式 C14H15ClN2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

CC(N1)=C(C2=CCNCC2)C3=C1C=CC(Cl)=C3

参考文献

1. Mattsson et al. Bioorg.Med.Chem.Lett., 2005;15:4230.

2. Nikiforuk A, et al. Psychopharmacology (Berl). 2011 Oct;217(3):411-8.

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