EMA401 |CAS:1316755-16-4 Probechem Biochemicals

Chemical Structure : EMA401

CAS No.: 1316755-16-4

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EMA401 (EMA 401;EMA-401;Olodanrigan)

货号: PC-43383Not For Human Use, Lab Use Only.

EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM.

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生物&药学活性

EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM.
EMA401 is a novel peripherally-restricted analgesic, may act on paracrine/autocrine mechanisms at peripheral nerve terminals, or intracrine mechanisms, to reduce neuropathic pain signalling in AngII/NGF/TRPV1-convergent pathways.

物理化学性质&存储条件

分子量	507.5764
分子式	C32H29NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	3-Isoquinolinecarboxylic acid, 2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-, (3S)-

参考文献

1. Anand U, et al. Eur J Pain. 2013 Aug;17(7):1012-26.

2. Smith MT, et al. Pain Med. 2013 May;14(5):692-705.

3. Rice ASC, et al. Lancet. 2014 May 10;383(9929):1637-1647.

4. Anand U, et al. Mol Pain. 2015 Jun 26;11:38.

EMA401 (EMA 401;EMA-401;Olodanrigan)

生物&药学活性

物理化学性质&存储条件

参考文献

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EMA401 (EMA 401;EMA-401;Olodanrigan)

生物&药学活性

物理化学性质&存储条件

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