EMA300 (PD121981)

Chemical Structure : EMA300

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货号: PC-62642Not For Human Use, Lab Use Only.

EMA300 (PD121981) is a potent, selective small molecule antagonist of angiotensin II type 2 receptor (AT2R) with >1,000-fold selectivity over AT1 receptor.

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生物&药学活性

EMA300 (PD121981) is a potent, selective small molecule antagonist of angiotensin II type 2 receptor (AT2R) with >1,000-fold selectivity over AT1 receptor.
EMA300 (PD121981) produces analgesia in rodent model of neuropathic pain.

物理化学性质&存储条件

分子量	495.579
分子式	C30H29N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-[(4-methoxy-3-methylphenyl)methyl]-, (S)- (9CI)

参考文献

1. Smith MT, et al. Pain Med. 2013 Oct;14(10):1557-68.

2. Smith MT, et al. Behav Pharmacol. 2014 Apr;25(2):137-46.

3. Khan N, et al. Front Mol Neurosci. 2017 Nov 21;10:389.

4. Smith MT, et al. Pain Med. 2013 May;14(5):692-705.

EMA300 (PD121981)

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物理化学性质&存储条件

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EMA300 (PD121981)

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