ELOVL1-IN-27

Chemical Structure : ELOVL1-IN-27

加入收藏

货号: PC-38655Not For Human Use, Lab Use Only.

ELOVL1-IN-27 is a highly potent, selective, CNS-penetrant inhibitor of elongation of very long chain fatty acid 1 enzyme (ELOVL1) with IC50 of 13 nM (C26:0 VLCFA inhibition in HEK cell).

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ELOVL1-IN-27 is a highly potent, selective, CNS-penetrant inhibitor of elongation of very long chain fatty acid 1 enzyme (ELOVL1) with IC50 of 13 nM (C26:0 VLCFA inhibition in HEK cell).
ELOVL1-IN-27 selectively inhibits ELOVL1, reducing C26:0 VLCFA synthesis in ALD patient fibroblasts, lymphocytes, and microglia.
ELOVL1-IN-27 reduced C26:0 very long chain fatty acid (VLCFA) concentrations to near-wild-type levels in blood and up to 65% in the brain, a disease-relevant tissue in mouse models of adrenoleukodystrophy (ALD).

物理化学性质&存储条件

分子量	340.334
分子式	C18H14F2N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-fluorophenyl)-N-(1-(2-fluoropyridin-4-yl)-1H-pyrazol-3-yl)cyclopropane-1-carboxamide

参考文献

1. Jon H Come, et al. J Med Chem. 2021 Dec 23;64(24):17753-17776.

ELOVL1-IN-27

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ELOVL1-IN-27

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.