ELOVL1-IN-22 | ELOVL1 inhibitor | Probechem Biochemicals

Chemical Structure : ELOVL1-IN-22

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ELOVL1-IN-22 (2761063-99-2)

货号: PC-72515Not For Human Use, Lab Use Only.

ELOVL1-IN-22 is a potent, selective, CNS-penetran inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme, reduces C26:0 VLCFA synthesis in HEK293 with EC50 of 0.4 nM.

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生物&药学活性

ELOVL1-IN-22 is a potent, selective, CNS-penetrant, orally bioavailable inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme, reduces C26:0 VLCFA synthesis in HEK293 with EC50 of 0.4 nM.
ELOVL1-IN-22 reduced C26:0 VLCFA synthesis in ALD patient fibroblasts and lymphocytes in vitro.
ELOVL1-IN-22 reduced C26:0 lysophosphatidyl choline (LPC), a subtype of VLCFA, in the blood of ATP binding cassette transporter D1 (ABCD1) KO mice, a murine model of ALD to near wild-type levels.
ELOVL1-IN-22 is a useful tool for exploring therapeutic approaches to the treatment of adrenoleukodystrophy (ALD).

物理化学性质&存储条件

分子量	377.448
分子式	C21H23N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-Phenyl-4-[6-[[cis-3-(1H-pyrazol-1-yl)cyclobutyl]oxy]-4-pyrimidinyl]morpholine

参考文献

1. Michael J Boyd, et al. J Med Chem. 2021 Dec 23;64(24):17777-17794.

ELOVL1-IN-22 (2761063-99-2)

生物&药学活性

物理化学性质&存储条件

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ELOVL1-IN-22 (2761063-99-2)

生物&药学活性

物理化学性质&存储条件

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