ELOVL1-IN-1

Chemical Structure : ELOVL1-IN-1

CAS No.: 2227482-41-7

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货号: PC-38655Not For Human Use, Lab Use Only.

ELOVL1-IN-1 is a highly potent, selective, CNS-penetrant inhibitor of elongation of very long chain fatty acid 1 enzyme (ELOVL1) with IC50 of 13 nM (C26:0 VLCFA inhibition in HEK cell).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ELOVL1-IN-1 is a highly potent, selective, CNS-penetrant inhibitor of elongation of very long chain fatty acid 1 enzyme (ELOVL1) with IC50 of 13 nM (C26:0 VLCFA inhibition in HEK cell).
ELOVL1-IN-1 selectively inhibits ELOVL1, reducing C26:0 VLCFA synthesis in ALD patient fibroblasts, lymphocytes, and microglia.
ELOVL1-IN-1 reduced C26:0 very long chain fatty acid (VLCFA) concentrations to near-wild-type levels in blood and up to 65% in the brain, a disease-relevant tissue in mouse models of adrenoleukodystrophy (ALD).

物理化学性质&存储条件

分子量	340.334
分子式	C18H14F2N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-fluorophenyl)-N-(1-(2-fluoropyridin-4-yl)-1H-pyrazol-3-yl)cyclopropane-1-carboxamide

参考文献

1. Jon H Come, et al. J Med Chem. 2021 Dec 23;64(24):17753-17776.

ELOVL1-IN-1

生物&药学活性

物理化学性质&存储条件

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ELOVL1-IN-1

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物理化学性质&存储条件

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