EGPI-1 | eIF4E/eIF4G inhibitor | Probechem Biochemicals

Chemical Structure : EGPI-1

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EGPI-1 (EGPI1)

货号: PC-72234Not For Human Use, Lab Use Only.

EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction.
EGPI-1 has potent antiproliferative and proapoptotic activity in multiple myeloma cells, Jurkat cells, and A549 lung cancer cell lines, inhibits A549 proliferation with IC50 of 2.61 uM, which is better than that of 4EGI-1 (IC50=58.6 uM), inhibits cancer cell growth by inhibiting eIF4E phosphorylation and inhibiting PI3K/Akt/mTOR signal pathway.
EGPI-1 induces autophagy, apoptosis, G0/G1 cell cycle arrest and ROS generation in A549 cells, disrupts the mitochondrial membrane potential (∆ψ m).
EGPI-1 demonstrated in vivo anti-tumor activities in A549-xenografted athymic mice (25 mg/kg/day, 50 mg/kg/day, i.p.).

物理化学性质&存储条件

分子量	383.34
分子式	C17H10F5N3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(2-(3,4-difluorobenzylidene)hydrazinyl)-4-(4-(trifluoromethyl)phenyl)thiazole

参考文献

1. Lijun Wang, et al. Eur J Med Chem. 2019 Sep 1;177:153-170.

2. Qi X, et al. Chem Biol Interact. 2022 Jan 25;352:109773.

EGPI-1 (EGPI1)

生物&药学活性

物理化学性质&存储条件

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EGPI-1 (EGPI1)

生物&药学活性

物理化学性质&存储条件

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