EGFR inhibitor 57

Chemical Structure : EGFR inhibitor 57

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货号: PC-49365Not For Human Use, Lab Use Only.

EGFR inhibitor 57 is a novel potent, selective, allosteric fourth-generation EGFR L858R inhibitor, overcomes EGFRC797S-mediated resistance in NSCLC harboring the activating EGFRL858R mutation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

EGFR inhibitor 57 is a novel potent, selective, allosteric fourth-generation EGFR L858R inhibitor, overcomes EGFRC797S-mediated resistance in NSCLC harboring the activating EGFRL858R mutation.
EGFR inhibitor 57 is the first allosteric EGFR inhibitor that demonstrates robust tumor regression in a mutant EGFRL858R/C797S tumor model.
EGFR inhibitor 57 is active in an H1975 EGFRL858R/T790M NSCLC xenograft model and shows superior efficacy in combination with osimertinib compared to the single agents.

物理化学性质&存储条件

分子量	681.81
分子式	C37H37F2N7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(difluoromethyl)-6-((4-((4-(hydroxymethyl)piperidin-1-yl)methyl)phenyl)ethynyl)-7-methyl-2H-indazol-2-yl)-2-(6',7'-dihydrospiro[cyclopropane-1,5'-pyrrolo[1,2-c]imidazol]-1'-yl)-N-(thiazol-2-yl)acetamide

参考文献

1. Ulrike Obst-Sander, Journal of Medicinal Chemistry, 2022.