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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-EG00229 free base
EG00229 free base

Chemical Structure : EG00229 free base

CAS No.: 1018927-63-3

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EG00229 free base (EG 00229, EG-00229)

货号: PC-35130Not For Human Use, Lab Use Only.

EG00229 is a specific inhibitor of neuropilin-1 (NRP1)/VEGF-A interaction, inhibits the binding of biotinylated VEGFA to NRP1 with IC50 of 8 uM.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EG00229 is a specific inhibitor of neuropilin-1 (NRP1)/VEGF-A interaction, inhibits the binding of biotinylated VEGFA to NRP1 with IC50 of 8 uM.
EG00229 also demonstrates to have functional effects on cell-migration and VEGF-R2 phosphorylation.

物理化学性质&存储条件

分子量 497.563
分子式 C17H19N7O5S3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-((diaminomethylene)amino)pentanoic acid

参考文献

1. Powell J, et al. J Med Chem. 2018 May 10;61(9):4135-4154.

2. Jarvis A, et al. J Med Chem. 2010 Mar 11;53(5):2215-26.

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