ECIN (E. coli inhibitor)

Chemical Structure : ECIN (E. coli inhibitor)

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货号: PC-22508Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ECIN (E. coli inhibitor) is a copper-responsive small molecule inhibitor of wild-type uropathogenic Escherichia coli (UPEC) strains with IC50 of 336 ng/mL in the absence of copper, and 260 and 128 ng/mL in the presence of 25 and 250 µM copper, respectively.
ECIN has a broad spectrum of activity against pathogens of medical and veterinary significance including Acinetobacter baumannii, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus.
ECIN induces copper stress by increasing the cell-associated copper content in UPEC.
ECIN has a broad spectrum of activity against a diverse array of pathogens (MIC<1.3 ug/mL) and is bactericidal against UPEC.
ECIN prevents biofilm formation but does not eradicate existing biofilms.
ECIN upregulates several bacterial stress response systems in UPEC, supplementation of cysteine inhibits the activity of ECIN.

物理化学性质&存储条件

分子量	260.13
分子式	C10H7Cl2NOS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-2-(4-chlorophenyl)−4-methyl-2,3-dihydro-1,2-thiazol-3-one

参考文献

1. Braden S Hanson, et al. J Bacteriol. 2024 Jun 10:e0011224.