EC359 | LIFR inhibitor | Probechem Biochemicals

Chemical Structure : EC359

CAS No.: 2012591-09-0

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EC359 (EC-359)

货号: PC-35333Not For Human Use, Lab Use Only.

EC359 (EC-359) is a first-in-class, orally available inhibitor of leukemia inhibitory factor (LIF), blocks LIF-LIFR interaction and binds to LIFR with affinity of 81 nM in SPR assay.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

EC359 (EC-359) is a first-in-class, orally available inhibitor of leukemia inhibitory factor (LIF), blocks LIF-LIFR interaction and binds to LIFR with affinity of 81 nM in SPR assay.
EC-359 displays limited binding to classical steroid receptors.
EC-359 shows cytoskeletal disruption and targeting cancer-associated fibroblasts (CAFs) through inhibition of alpha-SMA but not beta-tubulin, reduces the STAT3 phosphorylation, mTOR and further downstream signaling cascades.
EC-359 dose dependently reduces tumor burden in both TNBC xenograft and murine syngeneic MM51 models (1 and 5 mg/kg dose).

物理化学性质&存储条件

分子量	571.715
分子式	C36H38F2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(8S,11R,13S,14S,17S)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-11-(2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

参考文献

1. Hareesh B. Nair, et al. Abstract LB-B04: Development of a first-in-class leukemia inhibitory factor (LIF)/LIFR inhibitor, EC359 for targeted therapy

EC359 (EC-359)

生物&药学活性

物理化学性质&存储条件

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EC359 (EC-359)

生物&药学活性

物理化学性质&存储条件

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