EC-70124 |CAS:1185908-92-2 Probechem Biochemicals

Chemical Structure : EC-70124

加入收藏

EC-70124 (EC70124)

货号: PC-63517Not For Human Use, Lab Use Only.

EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM).

规格	价格	库存	数量
10 mg		Get quote
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM).
EC-70124 inhibits 7 out of 9 FLT3 mutants, also acts as a dual STAT3/NF-kB inhibitor, reverting both tumorigenic and stem cell properties in prostate cancer.
EC-70124 inhibits AML cell proliferation and induces cell cycle arrest and apoptosis.
EC-70124 in vivo oral treatment causes complete regression in AML tumor xenograft models, and ex vivo inhibits proliferation in AML patient blasts at biochemically relevant doses.

物理化学性质&存储条件

分子量	453.454
分子式	C26H19N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5R,7S,9S)-7,8-dihydroxy-9-methyl-6,7,8,9-tetrahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacene-14,16(15H)-dione

参考文献

1. Civenni G, et al. Mol Cancer Ther. 2016 May;15(5):806-18.

2. Cuenca-López MD, et al. Oncotarget. 2015 Sep 29;6(29):27923-37.

3. Puente-Moncada N, et al.

4. Sánchez C, et al. Chem Commun (Camb). 2009 Jul 21;(27):4118-20.

EC-70124 (EC70124)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

EC-70124 (EC70124)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.