EC-11716 | Tuberculosis gyrase inhibitor | Probechem Biochemicals

Chemical Structure : EC-11716

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EC-11716 (EC/11716)

货号: PC-72693Not For Human Use, Lab Use Only.

EC-11716 (EC/11716) is a novel mycobacterium tuberculosis gyrase inhibitor with potent anti-tubercular activity (MIC 0.38 uM, M. tuberculosis H37Rv).

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生物&药学活性

EC-11716 (EC/11716) is a novel mycobacterium tuberculosis gyrase inhibitor with potent anti-tubercular activity (MIC 0.38 uM, M. tuberculosis H37Rv).
EC/11716 is active against M. abscessus subspecies and clinical isolates, maintains comparable activity against a panel of clinical isolates covering the M. abscessus complex.
EC/11716 is effective against M. abscessus biofilms (MIC 0.78 uM), with better bactericidal activity against biofilms than moxifloxacin.
EC/11716 is active against M. abscessus in vivo.

物理化学性质&存储条件

分子量	457.959
分子式	C23H28ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(4-(((5-chloro-6-(hydroxymethyl)pyridin-3-yl)methyl)amino)piperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one

参考文献

1. Uday S Ganapathy, et al. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0151421.

EC-11716 (EC/11716)

生物&药学活性

物理化学性质&存储条件

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EC-11716 (EC/11716)

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物理化学性质&存储条件

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