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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-EBL-3647
EBL-3647

Chemical Structure : EBL-3647

CAS No.: 2851907-60-1

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EBL-3647 (EBL3647)

货号: PC-22092Not For Human Use, Lab Use Only.

EBL-3647 is a novel LpxH inhibitor with IC50 of 2.2 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 0.5 mg/mL).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EBL-3647 is a novel LpxH inhibitor with IC50 of 2.2 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 0.5 mg/mL).
EBL-3647 has potent in vivo efficacy against bloodstream infections caused by the critical Gram-negative pathogens E. coli and Klebsiella pneumoniae.
EBL-3647 has potent in vitro activity against a diverse range of clinical E. coli and K. pneumoniae isolates, irrespective of the resistance genotype.

物理化学性质&存储条件

分子量 667.80
分子式 C30H37N9O5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((3-(aminomethyl)azetidin-1-yl)methyl)-N-(4-((4-(4-cyano-6-methylpyrimidin-2-yl)piperazin-1-yl)sulfonyl)phenyl)-2-(N-methylmethylsulfonamido)benzamide

参考文献

1. Huseby DL, et al. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317274121.

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