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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-EBL-3599
EBL-3599

Chemical Structure : EBL-3599

CAS No.: 2851907-53-2

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EBL-3599 (EBL3599)

货号: PC-22091Not For Human Use, Lab Use Only.

EBL-3599 is a novel LpxH inhibitor with IC50 of 3.5 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 1 mg/mL).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    EBL-3599 is a novel LpxH inhibitor with IC50 of 3.5 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 1 mg/mL).
    EBL-3599 has potent in vivo efficacy against bloodstream infections caused by the critical Gram-negative pathogens E. coli and Klebsiella pneumoniae.
    EBL-3599 has potent in vitro activity against a diverse range of clinical E. coli and K. pneumoniae isolates, irrespective of the resistance genotype.

    物理化学性质&存储条件

    分子量 655.79
    分子式 C29H37N9O5S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(((3-aminopropyl)amino)methyl)-N-(4-((4-(4-cyano-6-methylpyrimidin-2-yl)piperazin-1-yl)sulfonyl)phenyl)-2-(N-methylmethylsulfonamido)benzamide

    参考文献

    1. Huseby DL, et al. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317274121.

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