EB-3D | ChoKα inhibitor | Probechem Biochemicals

Chemical Structure : EB-3D

CAS No.: 1839150-63-8

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EB-3D (ChoKα inhibitor EB-3D)

货号: PC-35395Not For Human Use, Lab Use Only.

EB-3D is a novel potent and selective choline kinase ChoKα inhibitor with IC50 of 1.0 uM (purified ChoKα1), strongly impairs cell proliferation in a variety of different cancer cell lines.

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5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

EB-3D is a potent and selective choline kinase ChoKα inhibitor with IC50 of 1.0 uM (purified ChoKα1), strongly impairs cell proliferation in a variety of different cancer cell lines.
EB-3D demonstrates in vitro antiproliferative effects against HeLa (IC50=79 nM), RS4,11 (IC50=45 nM), A549 (IC50=27 nM) and MDA-MB-231 (IC50=100 nM).
EB-3D displays excellent antiproliferative activity against a wide cohort of T-leukemic cell lines with GI50 of 0.9 nM (MOLT-16 cell)-479 nM (CCRF-CEM), reduces the intracellular pool of PCho, but also inhibits the synthesis of choline-containing lipids.
induces G0/G1 arrest that lead to apoptosis in leukemia cell lines; affects AMPK-mTOR signaling pathway, synergizes with both dexamethasone and L-asparaginase.

物理化学性质&存储条件

分子量	644.452
分子式	C30H36Br2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridinium) bromide

参考文献

1. Schiaffino-Ortega S, et al. Sci Rep. 2016 Mar 31;6:23793.

2. Mariotto E, et al. Biochem Pharmacol. 2018 Jul 10. pii: S0006-2952(18)30272-7.

EB-3D (ChoKα inhibitor EB-3D)

生物&药学活性

物理化学性质&存储条件

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EB-3D (ChoKα inhibitor EB-3D)

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物理化学性质&存储条件

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